Can You Take Zyrtec-D And Sudafed Together? In our latest question and answer, the pharmacist discusses whether or not Zyrtec-D and Sudafed can safely be taken together. Symptoms Treated Runny Nose Headache Sinus Pressure/Congestion Aches/Pain Sneezing Itchy/Watery/Red Eyes Itching of Nose/Throat Active Ingredients Chlorpheniramine Maleate 2 mg (antihistamine) Pseudoephedrine is a stimulant, but it is well known for shrinking swollen nasal mucous membranes, so it is often used as a decongestant. It reduces tissue hyperemia, edema, and nasal congestion commonly associated with colds or allergies. I think Zyrtec is blocking it off as much as it can. I was thinking about taking flonase, I did some research and what I found out was that it's a steriod. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. When your nose is blocked because of sinusitis, it can feel like your whole day has been ruined. SUDAFED ® Sinus Ease 0.1% Nasal Spray is here to help, targeting sinus congestion when sprayed directly into your nose, to help you breathe more easily. Worked for the most part I always used to take sudafed for congestion that helped but I feel adding the benadryl to it helps a little more and I can take it at night. Our best-selling SUDAFED® Nasal Spray targets the source of congestion & gets to work in minutes, helping clear your nose & relieve discomfort. Click here for details! What should I avoid while taking Sudafed PE Sinus & Allergy? This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Diphenhydramine comes as a tablet, a rapidly disintegrating (dissolving) tablet, a capsule, a liquid-filled capsule, a dissolving strip, powder, and a liquid to take by mouth.